Engineering Endogenous Tumor?Associated Macrophage?Targeted Biomimetic Nano?RBC to Reprogram Tumor Immunosuppressive Microenvironment for Enhanced Chemo?Immunotherapy (Adv. Mater. 39/2021)
نویسندگان
چکیده
Cancer Chemo-Immunotherapy In article number 2103497, Yubin Huang, Dongfang Zhou, and co-workers demonstrate an engineered endogenous tumor-associated macrophages (TAMs)-targeting biomimetic nano-red-blood-cell (RBC) system to deliver chemotherapeutic doxorubicin oxygen for enhanced cancer chemo-immunotherapy. TAMs-targeting depletion hypoxia alleviation synergistically reprogram the tumor immunosuppressive microenvironment. The ensuing TAMs-targeted chemo-immunotherapeutic effects markedly inhibit metastasis recurrence.
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ژورنال
عنوان ژورنال: Advanced Materials
سال: 2021
ISSN: ['1521-4095', '0935-9648']
DOI: https://doi.org/10.1002/adma.202170304